Rescue of interferon induced bone marrow aplasia in a patient with chronic myeloid leukemia by allogeneic bone marrow transplant

A Alabdulaaly; J Rifkind; H Solow; H A Messner; J H Lipton

doi:10.1080/1042819031000139774

Rescue of interferon induced bone marrow aplasia in a patient with chronic myeloid leukemia by allogeneic bone marrow transplant

Leuk Lymphoma. 2004 Jan;45(1):175-7. doi: 10.1080/1042819031000139774.

Authors

A Alabdulaaly¹, J Rifkind, H Solow, H A Messner, J H Lipton

Affiliation

¹ Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ont, Canada, M5G 2M9.

PMID: 15061216
DOI: 10.1080/1042819031000139774

Abstract

A patient with chronic phase Philadelphia chromosome positive CML, developed severe protracted bone marrow hypoplasia after interferon therapy. This complication did not respond to two courses of immunosuppressive therapy with anti-thymocyte globulin, cyclosporin A and prednisone. The patient continued to be transfusion dependent with persistence of Philadelphia chromosome. Allogeneic BMT restored normal hematopoeisis.

Publication types

Case Reports

MeSH terms

Adult
Bone Marrow / abnormalities*
Bone Marrow Diseases / chemically induced
Bone Marrow Diseases / complications*
Bone Marrow Diseases / pathology
Bone Marrow Diseases / surgery*
Bone Marrow Transplantation*
Female
Humans
Interferon-alpha / adverse effects*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
Transplantation, Homologous

Substances

Interferon-alpha