Collagen, ageing and nutrition

Clin Chem Lab Med. 2004 Jan;42(1):9-12. doi: 10.1515/CCLM.2004.003.


The relationship between ageing and nutrition is considered with collagen as the intermediate target. Some data showed that diet restriction resulted in decreased collagen accumulation and collagen ageing. Conversely, being overweight reduced the lifespan and increased collagen ageing. Collagen ageing, which includes low turnover and glycoxidation, involves an increase in both stiffness and weakness. Their consequences concern all tissues including those with vital importance such as cartilage, heart ventricle or arterial wall.

MeSH terms

  • Aging / physiology*
  • Animals
  • Caloric Restriction
  • Collagen / metabolism*
  • Diet
  • Humans
  • Nutritional Physiological Phenomena*
  • Oxidative Stress


  • Collagen