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Review
, 19 (4), 380-9

Effect of Supplemental Vitamin E for the Prevention and Treatment of Cardiovascular Disease

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Review

Effect of Supplemental Vitamin E for the Prevention and Treatment of Cardiovascular Disease

Paul G Shekelle et al. J Gen Intern Med.

Abstract

Objective: To evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease.

Design: Systematic review of placebo-controlled randomized controlled trials; meta-analysis where justified.

Measurements and main results: Eighty-four eligible trials were identified. For the outcomes of all-cause mortality, cardiovascular mortality, fatal or nonfatal myocardial infarction, and blood lipids, neither supplements of vitamin E alone nor vitamin E given with other agents yielded a statistically significant beneficial or adverse pooled relative risk (for example, pooled relative risk of vitamin E alone = 0.96 [95% confidence interval (CI), 0.84 to 1.10]; 0.97 [95% CI, 0.80 to 1.90]; and 0.72 [95% CI, 0.51 to 1.02] for all-cause mortality, cardiovascular mortality, and nonfatal myocardial infarction, respectively.

Conclusions: There is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes.

Figures

FIGURE 1
FIGURE 1
Flowchart of trials.
FIGURE 2
FIGURE 2
Pooled relative risk ratios for all-cause mortality.
FIGURE 3
FIGURE 3
Pooled relative risk ratios for myocardial infarction.

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