Signal transduction: implications for Ras-dependent ERK signaling

Curr Biol. 2004 Apr 6;14(7):R277-8. doi: 10.1016/j.cub.2004.03.023.


Ras interacts with numerous downstream effectors to transmit a diverse array of cellular signals. A new study shows that a protein known as Impedes Mitogenic signal Propagation, IMP, is an E3 ubiquitin ligase that binds Ras and modulates MAP kinase signaling by regulating the scaffolding activity of KSR.

Publication types

  • Review

MeSH terms

  • Mitogen-Activated Protein Kinases / metabolism*
  • Models, Biological*
  • Protein Kinases / metabolism*
  • Signal Transduction*
  • Ubiquitin-Protein Ligases / metabolism*
  • Xenopus Proteins / metabolism*
  • ras Proteins / metabolism*


  • Xenopus Proteins
  • IMP protein, Xenopus
  • Ubiquitin-Protein Ligases
  • Protein Kinases
  • KSR-1 protein kinase
  • Mitogen-Activated Protein Kinases
  • ras Proteins