Amiodarone pulmonary toxicity

Clin Chest Med. 2004 Mar;25(1):65-75. doi: 10.1016/S0272-5231(03)00144-8.


The amount of literature on amiodarone pulmonary toxicity (APT) peaked in 1983-1984 with several hundred cases reported cumulatively, and declined thereafter. Since the mid-1990s, publications have increased, which suggests that APT remains a current problem in clinical practice. Amiodarone remains difficult to diagnose noninvasively, and although the outcome is good in the majority of patients, not all cases of APT can be controlled satisfactorily.

Publication types

  • Review

MeSH terms

  • Amiodarone / adverse effects*
  • Amiodarone / pharmacokinetics
  • Amiodarone / therapeutic use
  • Anti-Arrhythmia Agents / adverse effects*
  • Anti-Arrhythmia Agents / pharmacokinetics
  • Anti-Arrhythmia Agents / therapeutic use
  • Bronchoalveolar Lavage
  • Humans
  • Iatrogenic Disease
  • Lung / drug effects
  • Pleura / drug effects
  • Pleura / pathology
  • Pneumonia / chemically induced
  • Respiratory Function Tests


  • Anti-Arrhythmia Agents
  • Amiodarone