Drug-induced bronchiolitis obliterans organizing pneumonia

Clin Chest Med. 2004 Mar;25(1):89-94. doi: 10.1016/S0272-5231(03)00140-0.


Several medications have been associated with the development of the BOOP lesion. Often, symptoms include nonproductive cough and shortness of breath with bilateral crackles by examination. Occasionally, there is fever and rash, and, rarely, eosinophilia. The chest radiograph usually shows bilateral patchy infiltrates. In rare situations, the outcome is fatal, although cessation of the medication or treatment with corticosteroid therapy results in resolution of symptoms and radiographic abnormalities for most patients.

Publication types

  • Review

MeSH terms

  • Amiodarone / adverse effects
  • Anti-Arrhythmia Agents / adverse effects
  • Anti-Infective Agents, Urinary / adverse effects
  • Antineoplastic Agents / adverse effects
  • Cryptogenic Organizing Pneumonia / chemically induced*
  • Humans
  • Iatrogenic Disease
  • Nitrofurantoin / adverse effects


  • Anti-Arrhythmia Agents
  • Anti-Infective Agents, Urinary
  • Antineoplastic Agents
  • Nitrofurantoin
  • Amiodarone