Vaccination of pigs two weeks before infection significantly reduces transmission of foot-and-mouth disease virus

Vaccine. 2004 Mar 29;22(11-12):1372-8. doi: 10.1016/j.vaccine.2003.11.003.


The objective of this study was to investigate whether and at what time interval could vaccination reduce transmission of foot-and-mouth disease virus (FMDV) among pigs. Reduction of virus transmission by vaccination was determined experimentally. Transmission of FMDV was studied in three groups of ten pigs: one non-vaccinated group and two groups that were vaccinated 7 days (-7 dpi) and 14 days before inoculation (-14 dpi), respectively. Five randomly selected pigs from each group were inoculated with FMDV type O Taiwan, while the other five pigs left in the groups were exposed to the inoculated pigs by direct contact. Clinical signs were recorded, virus isolation and RT-PCR were carried out on oropharyngeal fluid (OPF), and the neutralizing antibody titres and the antibody response against non-structural (NS) proteins of FMDV were determined. No virus transmission was observed in the -14 dpi group, whereas virus transmission was observed in all contact pigs affecting both the non-vaccinated and the -7 dpi group. The reproduction ratio R in the -14 dpi vaccinated group was significantly lower than that of the non-vaccinated group. This study confirms the potential of vaccination as an important tool to reduce transmission of FMDV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / analysis
  • Antibodies, Viral / biosynthesis
  • Enzyme-Linked Immunosorbent Assay
  • Foot-and-Mouth Disease / physiopathology
  • Foot-and-Mouth Disease / prevention & control*
  • Foot-and-Mouth Disease / transmission*
  • Foot-and-Mouth Disease Virus / immunology
  • Foot-and-Mouth Disease Virus / isolation & purification
  • Neutralization Tests
  • Reverse Transcriptase Polymerase Chain Reaction
  • Swine
  • Swine Diseases / prevention & control*
  • Swine Diseases / transmission*
  • Vaccination*
  • Viral Vaccines / therapeutic use


  • Antibodies, Viral
  • Viral Vaccines