A link between transcription and intermediary metabolism: a role for Sir2 in the control of acetyl-coenzyme A synthetase

Curr Opin Microbiol. 2004 Apr;7(2):115-9. doi: 10.1016/j.mib.2004.02.005.


The silent information regulator protein (Sir2) and its homologs (collectively known as sirtuins) are NAD+-dependent deacetylase enzymes involved in chromosome stability, gene silencing and cell aging in eukaryotes and archaea. The discovery that sirtuin-dependent protein deacetylation is a NAD+-consuming reaction established a link with the energy generation systems of the cell. This link to metabolism was recently extended to the post-translational control of the activity of short-chain fatty acyl-coenzyme A (adenosine monophosphate-forming) synthetases in bacteria and yeast. The crystal structure of the Sir protein complexed with a peptide of a protein substrate provided insights into how sirtuins interact with their protein substrates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetate-CoA Ligase / metabolism*
  • Amino Acid Sequence
  • Molecular Sequence Data
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism
  • Salmonella enterica / genetics*
  • Salmonella enterica / metabolism
  • Sirtuins / genetics*
  • Sirtuins / metabolism*
  • Transcription, Genetic / physiology


  • Sirtuins
  • Acetate-CoA Ligase