Regulation of senescence by eukaryotic translation initiation factor 5A: implications for plant growth and development

Trends Plant Sci. 2004 Apr;9(4):174-9. doi: 10.1016/j.tplants.2004.02.008.


Regulation of protein synthesis is increasingly being recognized as an important determinant of cell proliferation and senescence. In particular, recent evidence indicates that eukaryotic translation initiation factor 5A (eIF-A) plays a pivotal role in this determination. Separate isoforms of eIF-5A appear to facilitate the translation of mRNAs required for cell division and cell death. This raises the possibility that eIF-5A isoforms are elements of a biological switch that is in one position in dividing cells and in another position in dying cells. Changes in the position of this putative switch in response to physiological and environmental cues are likely to have a significant impact on plant growth and development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging*
  • Amino Acid Sequence
  • Arabidopsis / genetics
  • Arabidopsis / growth & development
  • Arabidopsis / metabolism*
  • Cell Death
  • Cell Division
  • Cell Survival
  • Conserved Sequence
  • Gene Expression Regulation, Plant
  • Molecular Sequence Data
  • Peptide Initiation Factors / metabolism*
  • Peptide Initiation Factors / physiology
  • Protein Isoforms / metabolism
  • Protein Processing, Post-Translational
  • RNA-Binding Proteins / metabolism*
  • RNA-Binding Proteins / physiology


  • Peptide Initiation Factors
  • Protein Isoforms
  • RNA-Binding Proteins
  • eukaryotic translation initiation factor 5A