Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirements in laparoscopic cholecystectomy

Can J Anaesth. 2004 Apr;51(4):358-63. doi: 10.1007/BF03018240.

Abstract

Purpose: To evaluate the comparative preemptive effects of gabapentin and tramadol on postoperative pain and fentanyl requirement in laparoscopic cholecystectomy.

Methods: Four hundred fifty-nine ASA I and II patients were randomly assigned to receive 300 mg gabapentin, 100 mg tramadol or placebo in a double-blind manner two hours before laparoscopic cholecystectomy under general anesthesia. Postoperatively, patients' pain scores were recorded on a visual analogue scale every two hours for the initial 12 hr and thereafter every three hours for the next 12 hr. Patients received fentanyl 2 micro g*kg(-1) intravenously on demand. The total fentanyl consumption for each patient was recorded.

Results: Patients in the gabapentin group had significantly lower pain scores at all time intervals (2.65 +/- 3.00, 1.99 +/- 1.48, 1.40 +/- 0.95, 0.65 +/- 0.61) in comparison to tramadol (2.97 +/- 2.35, 2.37 +/- 1.45, 1.89 +/- 1.16, 0.87 +/- 0.50) and placebo (5.53 +/- 2.22, 3.33 +/- 1.37, 2.41 +/- 1.19, 1.19 +/- 0.56). Significantly less fentanyl was consumed in the gabapentin group (221.16 +/- 52.39 micro g) than in the tramadol (269.60 +/- 44.17 micro g) and placebo groups (355.86 +/- 42.04 micro g; P < 0.05). Sedation (33.98%), nausea/retching/vomiting (24.8%) were the commonest side effects in the gabapentin group whereas respiratory depression (3.9%) was the commonest in the tramadol group and vertigo (7.8%) in the placebo group.

Conclusion: Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirement in laparoscopic cholecystectomy.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acetates / adverse effects
  • Acetates / therapeutic use*
  • Adult
  • Amines*
  • Analgesia / methods
  • Analgesics / adverse effects
  • Analgesics / therapeutic use
  • Analgesics, Opioid / adverse effects
  • Analgesics, Opioid / therapeutic use
  • Analysis of Variance
  • Anesthetics, Intravenous / therapeutic use
  • Cholecystectomy*
  • Cyclohexanecarboxylic Acids*
  • Double-Blind Method
  • Female
  • Fentanyl / administration & dosage
  • Fentanyl / therapeutic use*
  • Gabapentin
  • Humans
  • Laparoscopy / methods*
  • Male
  • Pain Measurement
  • Pain, Postoperative / prevention & control*
  • Time Factors
  • Tramadol / adverse effects
  • Tramadol / therapeutic use*
  • Treatment Outcome
  • gamma-Aminobutyric Acid*

Substances

  • Acetates
  • Amines
  • Analgesics
  • Analgesics, Opioid
  • Anesthetics, Intravenous
  • Cyclohexanecarboxylic Acids
  • Tramadol
  • gamma-Aminobutyric Acid
  • Gabapentin
  • Fentanyl