No association between pre-diagnostic plasma C-reactive protein concentration and subsequent prostate cancer

Prostate. 2004 Jun 1;59(4):393-400. doi: 10.1002/pros.10368.


Background: We evaluated the association of pre-diagnostic plasma concentration of C-reactive protein, a sensitive, but non-specific indicator of inflammation, with subsequent risk of prostate cancer.

Methods: Included were 264 histologically confirmed prostate cancer cases and 264 age-matched controls who were participants in the CLUE II cohort of Washington County, MD. C-reactive protein was measured using a high-sensitivity immunoturbidimetric assay. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated from conditional logistic regression models by fourth of the C-reactive protein distribution with cutpoints based on the controls. The median concentrations from the lowest to highest fourth were 0.41, 1.03, 1.90, and 4.53 mg/L.

Results: Geometric mean plasma concentrations did not differ between the cases (1.24 +/- 2.94 mg/L) and controls (1.41 +/- 2.97 mg/L; P = 0.16). Compared to the bottom fourth, the ORs (95% CI) of prostate cancer were 1.29 (0.80-2.08), 0.98 (0.61-1.58), and 0.95 (0.57-1.58) for the second, third, and highest fourths (P trend = 0.66). These findings were unchanged after adjusting for body mass index (BMI) and cigarette smoking status or after excluding men with markedly elevated C-reactive protein, cases diagnosed during the first 2 years of follow-up, or controls who never had a PSA test. These findings did not differ by stage or grade of prostate cancer.

Conclusions: Pre-diagnostic plasma concentration of C-reactive protein was not associated with subsequent risk of prostate cancer.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • C-Reactive Protein / analysis*
  • Case-Control Studies
  • Humans
  • Immunoassay
  • Inflammation
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / etiology*
  • Risk Factors
  • Sensitivity and Specificity


  • C-Reactive Protein