Early decision; meiotic crossover interference prior to stable strand exchange and synapsis

Cell. 2004 Apr 2;117(1):9-15. doi: 10.1016/s0092-8674(04)00297-1.


During meiosis, DNA double-strand breaks ultimately yield two types of recombinants: crossovers (CO) and noncrossovers (NCO). Recent studies in budding yeast show the CO/NCO designation occurs before stable strand exchange and thus well before Holliday junction resolution. Chromosome synapsis occurs after CO/NCO designation and is not required for the regulated distribution of COs along chromosomes manifested as CO interference.

Publication types

  • Review
  • Comment

MeSH terms

  • Chromosome Pairing / genetics*
  • Chromosomes / genetics
  • Chromosomes / ultrastructure
  • DNA / genetics*
  • DNA, Cruciform / genetics*
  • Meiosis / genetics*
  • Models, Molecular
  • Mutation / genetics
  • Recombination, Genetic / genetics*
  • Saccharomyces cerevisiae / genetics


  • DNA, Cruciform
  • DNA