Axin: a master scaffold for multiple signaling pathways

Neurosignals. May-Jun 2004;13(3):99-113. doi: 10.1159/000076563.

Abstract

Axin was originally identified from the characterization of the Fused locus, the disruption of which leads to duplication of axis and embryonic lethality. It is a multidomain protein that interacts with multiple proteins and functions as a negative regulator of Wnt signaling by downregulating the beta-catenin levels. Recently, it was demonstrated that Axin also plays an important role in a JNK signaling pathway. Axin utilizes discriminatory domains for its distinct roles in the Wnt pathway and in the Axin/JNK pathway. Here we review the data that show how Axin regulates multiple signaling pathways by serving as a scaffold protein, controlling diverse cellular functions in proliferation, fate determination, and suppression of tumorigenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Axin Protein
  • Cytoskeletal Proteins / metabolism
  • Humans
  • Mitogen-Activated Protein Kinases / metabolism
  • Models, Biological
  • Proto-Oncogene Proteins / metabolism
  • Repressor Proteins / chemistry
  • Repressor Proteins / physiology*
  • Signal Transduction / physiology*
  • Trans-Activators / metabolism
  • Wnt Proteins
  • Zebrafish Proteins*
  • beta Catenin

Substances

  • Axin Protein
  • CTNNB1 protein, human
  • Cytoskeletal Proteins
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Trans-Activators
  • Wnt Proteins
  • Zebrafish Proteins
  • beta Catenin
  • Mitogen-Activated Protein Kinases