To live or die by the sword: the regulation of apoptosis by the proteasome

Dev Cell. 2004 Apr;6(4):460-1. doi: 10.1016/s1534-5807(04)00104-2.


The proteasome has been implicated in the control of apoptosis by modulating the levels of both pro- and antiapoptotic molecules. A recent study published in the April 9th issue of Molecular Cell reveals that caspase-dependent inactivation of the proteasome can amplify the activation of apoptosis.

Publication types

  • Review

MeSH terms

  • Apoptosis / physiology*
  • Caspases / metabolism*
  • Cysteine Endopeptidases / metabolism*
  • Multienzyme Complexes / metabolism*
  • Peptide Hydrolases / metabolism
  • Proteasome Endopeptidase Complex
  • Signal Transduction / physiology
  • Ubiquitin / metabolism


  • Multienzyme Complexes
  • Ubiquitin
  • Peptide Hydrolases
  • Caspases
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex