Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 6 (4), 463-77

Development by Self-Digestion: Molecular Mechanisms and Biological Functions of Autophagy

Affiliations
Review

Development by Self-Digestion: Molecular Mechanisms and Biological Functions of Autophagy

Beth Levine et al. Dev Cell.

Abstract

Autophagy is the major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles. It involves the rearrangement of subcellular membranes to sequester cargo for delivery to the lysosome where the sequestered material is degraded and recycled. For many decades, it has been known that autophagy occurs in a wide range of eukaryotic organisms and in multiple different cell types during starvation, cellular and tissue remodeling, and cell death. However, until recently, the functions of autophagy in normal development were largely unknown. The identification of a set of evolutionarily conserved genes that are essential for autophagy has opened up new frontiers for deciphering the role of autophagy in diverse biological processes. In this review, we summarize our current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development.

Similar articles

  • Autophagy: Healthy Eating and Self-Digestion for Gastroenterologists
    S Hussey et al. J Pediatr Gastroenterol Nutr 46 (5), 496-506. PMID 18493203. - Review
    Autophagy is an evolutionary conserved mechanism in eukaryotic cells that is known to process redundant or defective cellular proteins and organelles. The recent renewal …
  • Autophagy as a Regulated Pathway of Cellular Degradation
    DJ Klionsky et al. Science 290 (5497), 1717-21. PMID 11099404. - Review
    Macroautophagy is a dynamic process involving the rearrangement of subcellular membranes to sequester cytoplasm and organelles for delivery to the lysosome or vacuole whe …
  • Autophagosome Formation in Mammalian Cells
    N Mizushima et al. Cell Struct Funct 27 (6), 421-9. PMID 12576635. - Review
    Macroautophagy is an intracellular degradation system for the majority of proteins and some organelles. The molecular mechanism of autophagy has been extensively studied …
  • Molecular Mechanism and Regulation of Autophagy
    YP Yang et al. Acta Pharmacol Sin 26 (12), 1421-34. PMID 16297339. - Review
    Autophagy is a major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles in eukaryotic cells. A large number of intracellular/extracell …
  • Regulation Mechanisms and Signaling Pathways of Autophagy
    C He et al. Annu Rev Genet 43, 67-93. PMID 19653858. - Review
    Autophagy is a process of self-degradation of cellular components in which double-membrane autophagosomes sequester organelles or portions of cytosol and fuse with lysoso …
See all similar articles

Cited by 1,248 PubMed Central articles

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources

Feedback