RNA silencing in viral infections: insights from poliovirus

Virus Res. 2004 Jun 1;102(1):11-7. doi: 10.1016/j.virusres.2004.01.010.


RNA interference or RNA silencing is a dsRNA guided mechanism that mediates sequence specific degradation of RNA. The recent demonstration that RNA interference can be used to inhibit virus replication has initiated an exciting field of research: first, as a potential novel antiviral therapeutic approach and, second, as a tool for dissecting virus-host interactions. Here we review and discuss the current data and perspectives on the use of RNA interference in the study of poliovirus as a model for positive strand RNA viruses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Viral
  • Humans
  • Poliovirus / genetics
  • Poliovirus / physiology*
  • RNA Interference*
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / physiology*
  • Virus Diseases / prevention & control
  • Virus Diseases / therapy
  • Virus Diseases / virology
  • Virus Replication / genetics


  • RNA, Small Interfering