Crohn's-associated chronic recurrent multifocal osteomyelitis responsive to infliximab

J Pediatr. 2004 Apr;144(4):541-4. doi: 10.1016/j.jpeds.2003.12.038.


We report a case of chronic recurrent clavicular osteomyelitis in association with Crohn disease. Steroid therapy resulted in partial remission; however, intractable shoulder pain and an enlarging clavicular mass subsequently recurred. Infliximab therapy resulted in significant improvement in the degree of bone pain and resolution of the large sclerotic clavicular lesion.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal / therapeutic use*
  • Child
  • Chronic Disease
  • Clavicle*
  • Crohn Disease / complications
  • Crohn Disease / drug therapy*
  • Female
  • Gastrointestinal Agents / therapeutic use*
  • Humans
  • Infliximab
  • Osteomyelitis / complications
  • Osteomyelitis / drug therapy*
  • Pain / drug therapy
  • Pain / etiology


  • Antibodies, Monoclonal
  • Gastrointestinal Agents
  • Infliximab