Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp

Microbiology. 2004 Apr;150(Pt 4):785-793. doi: 10.1099/mic.0.26645-0.


Coronamycin is a complex of novel peptide antibiotics with activity against pythiaceous fungi and the human fungal pathogen Cryptococcus neoformans. It is also active against the malarial parasite, Plasmodium falciparum, with an IC(50) of 9.0 ng ml(-1). Coronamycin is produced by a verticillate Streptomyces sp. isolated as an endophyte from an epiphytic vine, Monstera sp., found in the Manu region of the upper Amazon of Peru. Bioassay-guided fractionation of the fermentation broths of this endophyte on silica gel and HPLC chromatography yielded two principal, inseparable, peptides with masses of 1217.9 and 1203.8 Da. Three other minor, but related components, are also present in the preparation. Amino acid analysis of coronamycin revealed residues of component 1, component 2, methionine, tyrosine and leucine at a ratio of 2:2:1:1:3. Other compounds with antifungal activities are also produced by this endophytic streptomycete.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Araceae / microbiology*
  • Araceae / ultrastructure
  • Bacteria / drug effects
  • Cell Line
  • Fungi / drug effects
  • Humans
  • Microbial Sensitivity Tests
  • Microscopy, Electron, Scanning
  • Molecular Sequence Data
  • Parasitic Sensitivity Tests
  • Peptides*
  • Plasmodium falciparum / drug effects
  • Sequence Analysis, DNA
  • Spores, Fungal / ultrastructure
  • Streptomyces / metabolism*
  • Streptomyces / ultrastructure


  • Anti-Bacterial Agents
  • Peptides

Associated data

  • GENBANK/AY327845