Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 304 (5668), 237-42

How Viruses Enter Animal Cells

Affiliations
Review

How Viruses Enter Animal Cells

Alicia E Smith et al. Science.

Abstract

Viruses replicate within living cells and use the cellular machinery for the synthesis of their genome and other components. To gain access, they have evolved a variety of elegant mechanisms to deliver their genes and accessory proteins into the host cell. Many animal viruses take advantage of endocytic pathways and rely on the cell to guide them through a complex entry and uncoating program. In the dialogue between the cell and the intruder, the cell provides critical cues that allow the virus to undergo molecular transformations that lead to successful internalization, intra-cellular transport, and uncoating.

Similar articles

  • Nuclear Import and Export of Viruses and Virus Genomes
    GR Whittaker et al. Virology 246 (1), 1-23. PMID 9656989. - Review
    Many viruses replicate in the nucleus of their animal and plant host cells. Nuclear import, export, and nucleo-cytoplasmic shuttling play a central role in their replicat …
  • Effects of Lipid Rafts on Dynamics of Retroviral Entry and Trafficking: Quantitative Analysis
    KI Lim et al. Biotechnol Bioeng 86 (6), 650-60. PMID 15137076.
    The association of cell surface receptors with sterol-sphingolipid-enriched microdomains of the plasma membrane, so-called lipid rafts, may affect the receptor-mediated e …
  • Come in and Take Your Coat Off - How Host Cells Provide Endocytosis for Virus Entry
    M Schelhaas. Cell Microbiol 12 (10), 1378-88. PMID 20678171. - Review
    Viruses are intracellular parasites that rely upon the host cell machinery for their life cycle. Newly generated virus particles have to transmit their genomic informatio …
  • Viral Entry Into the Nucleus
    GR Whittaker et al. Annu Rev Cell Dev Biol 16, 627-51. PMID 11031249. - Review
    Because many viruses replicate in the nucleus of their host cells, they must have ways of transporting their genome and other components into and out of this compartment. …
  • Virus Entry Paradigms
    M Kalia et al. Amino Acids 41 (5), 1147-57. PMID 19826903. - Review
    Viruses, despite being relatively simple in structure and composition, have evolved to exploit complex cellular processes for their replication in the host cell. After bi …
See all similar articles

Cited by 218 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback