The correlation between plasma homocysteine and malondialdehyde levels in preeclampsia

Neuro Endocrinol Lett. 2003 Dec;24(6):445-8.


Objective: To investigate the possible correlation between plasma malondialdehyde and homocysteine levels of preeclamptic patients.

Design: Venous blood samples of 20 preeclamptics and 20 healthy pregnant controls were collected. Plasma malondialdehyde and homocysteine concentrations were measured and the correlation between them was investigated. Mann Whitney U test and Spearman correlation analysis were used for statistical analysis.

Setting: University of Firat, Medical School.

Results: Plasma malondialdehyde and homocysteine concentrations were higher in preeclamptic patients (p<0.05) and a positive correlation between these parameters was found (r: 0.77, p<0.01, n:20).

Conclusion: Our results may put forward some new strategies in the research of etiopathogenesis and treatment of preeclampsia.

MeSH terms

  • Adult
  • Female
  • Homocysteine / blood*
  • Humans
  • Lipid Peroxidation
  • Lipid Peroxides / metabolism
  • Malondialdehyde / blood*
  • Pre-Eclampsia / blood*
  • Pre-Eclampsia / etiology*
  • Pregnancy
  • Severity of Illness Index


  • Lipid Peroxides
  • Homocysteine
  • Malondialdehyde