[Dientamoeba fragilis: possibly an important cause of persistent abdominal pain in children]

Ned Tijdschr Geneeskd. 2004 Mar 20;148(12):575-9.
[Article in Dutch]


Objective: To determine the effect of an antiprotozoic treatment on children with persistent abdominal pain and infection with Dientamoeba fragilis.

Design: Retrospective.

Method: A total of 43 children with D. fragilis infection and persistent gastrointestinal complaints were included in the study. Of these 27 were treated with clioquinol and 16 with a nitroimidazole drug: metronidazole or tinidazole. The parasitological and clinical effects of the treatment were assessed.

Results: In 33 of the 43 (77%) children, no parasites were detected during follow-up with a triple faeces test: 22/27 following treatment with clioquinol and 11/16 following treatment with a nitroimidazole drug. In 27 of the 33 (82%) children with a negative follow-up result, gastrointestinal complaints were considerably less or had completely disappeared. In 2 of the 10 (20%) children in which D. fragilis had not disappeared in the follow-up period, the complaints were less or had disappeared.

Conclusion: Effective treatment of D. fragilis infection in children with longstanding gastrointestinal complaints often resulted in a reduction or disappearance of the complaints.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Abdominal Pain / drug therapy
  • Abdominal Pain / parasitology*
  • Animals
  • Antiprotozoal Agents / pharmacology
  • Antiprotozoal Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Dientamoeba / drug effects*
  • Dientamoeba / isolation & purification
  • Dientamoebiasis / complications
  • Dientamoebiasis / diagnosis*
  • Dientamoebiasis / drug therapy
  • Feces / parasitology
  • Female
  • Humans
  • Male
  • Retrospective Studies
  • Treatment Outcome


  • Antiprotozoal Agents