The Genome Sequence of the Anaerobic, Sulfate-Reducing Bacterium Desulfovibrio Vulgaris Hildenborough

Nat Biotechnol. 2004 May;22(5):554-9. doi: 10.1038/nbt959. Epub 2004 Apr 11.

Abstract

Desulfovibrio vulgaris Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome sequence reveals a network of novel c-type cytochromes, connecting multiple periplasmic hydrogenases and formate dehydrogenases, as a key feature of its energy metabolism. The relative arrangement of genes encoding enzymes for energy transduction, together with inferred cellular location of the enzymes, provides a basis for proposing an expansion to the 'hydrogen-cycling' model for increasing energy efficiency in this bacterium. Plasmid-encoded functions include modification of cell surface components, nitrogen fixation and a type-III protein secretion system. This genome sequence represents a substantial step toward the elucidation of pathways for reduction (and bioremediation) of pollutants such as uranium and chromium and offers a new starting point for defining this organism's complex anaerobic respiration.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Desulfovibrio vulgaris / genetics*
  • Desulfovibrio vulgaris / metabolism
  • Energy Metabolism
  • Genome, Bacterial*
  • Molecular Sequence Data

Associated data

  • GENBANK/AE017285
  • GENBANK/AE017286