Sociotropy and autonomy are conceptualized as two personality dimensions that relate to individuals' vulnerability to anxiety and depression. Sociotropy is characterized as an excessive investment in interpersonal relationships, and autonomy is characterized as an excessive concern with independence as well as a lack of concern for others. The present study investigated the relationships between sociotropy-autonomy and trait anxiety associated with four types of situations, i.e., Social Evaluation, Physical Danger, Ambiguous Situation, and Daily Routine. 255 undergraduate students completed the Sociotropy-Autonomy Scale, the Endler Multidimensional Anxiety Scale, and the Beck Depression Inventory. Analyses indicated that scores on Sociotropy were positively correlated with rated trait anxiety in situations of Social Evaluation, Physical Danger, and Ambiguous Situations, whereas scores on Autonomy were positively correlated with rated trait anxiety in Daily Routines. These findings are discussed in the context of the diathesis-stress model of anxiety and depression.