Differential desensitization of somatostatin receptor subtypes in atT-20 cells

Protein Pept Lett. 2004 Apr;11(2):141-7. doi: 10.2174/0929866043478239.


Nonpeptidyl agonists for the somatostatin (SRIF) receptor family have been developed. We have studied the desensitization effects for two of these agonists upon SRIF receptor function in AtT-20 cells, a neuroendocrine tumor cell, which endogenously expresses two distinct SRIF receptor, subtypes. We observe that SRIF and the nonpeptidyl, subtype selective agonists, differentially regulate SRIF receptor subtypes in the AtT-20 cell.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Colforsin / pharmacology
  • Cyclic AMP / metabolism
  • Mice
  • Receptors, Somatostatin / agonists
  • Receptors, Somatostatin / metabolism*
  • Signal Transduction* / drug effects
  • Somatostatin / analogs & derivatives
  • Somatostatin / metabolism*


  • Receptors, Somatostatin
  • Colforsin
  • Somatostatin
  • Cyclic AMP