[Relationship between six single nucleotide polymorphisms of angiotensinogen gene and essential hypertension]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Apr;21(2):116-9.
[Article in Chinese]

Abstract

Objective: To evaluate the relationship of six single nucleotide polymorphisms(SNPs) and their haplotypes of angiotensinogen(AGT) gene to essential hypertension(EH) in Chinese Han population.

Methods: The genotypes in 185 patients with EH and 185 healthy controls were determined by the method of ABI PRISM SNaPshot Multiplex Kit using six AGT gene polymorphisms at position -217(G/A), -152(G/A), -20(A/C) and -6(G/A) in the promoter region and T174M, M235T in exon 2.

Results: The distribution of AGT genotypes and alleles frequencies showed no significant difference between the group of EH and group of controls (P>0.05). However, haplotype analysis revealed that H4 haplotype frequency, which included -152A, -20C, -6A and 235T alleles, was significantly increased in the group of EH (P<0.05).

Conclusion: G-152A, A-20C, G-6A and M235T polymorphisms of AGT gene might play an important role in the occurrence of EH in Chinese Han population.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Angiotensinogen / blood
  • Angiotensinogen / genetics*
  • Female
  • Haplotypes
  • Humans
  • Hypertension / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*

Substances

  • Angiotensinogen