Synthesis and biochemical properties of E-ring modified luotonin A derivatives

Bioorg Med Chem Lett. 2004 May 3;14(9):2051-4. doi: 10.1016/j.bmcl.2004.02.069.

Abstract

Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Pyrroles / chemistry*
  • Pyrroles / pharmacology
  • Quinones / chemistry*
  • Quinones / pharmacology
  • Topoisomerase I Inhibitors

Substances

  • Enzyme Inhibitors
  • Pyrroles
  • Quinones
  • Topoisomerase I Inhibitors
  • luotonin A