Amygdala-frontal interactions and reward expectancy

Curr Opin Neurobiol. 2004 Apr;14(2):148-55. doi: 10.1016/j.conb.2004.03.007.


Recent evidence indicates that networks including the amygdala and prefrontal cortex provide a key interface between affect and cognition. Converging evidence from rodents, humans, and non-human primates indicates that interconnections between the basolateral complex of the amygdala and the orbitofrontal cortex are crucial to the formation and use of expectancies of reinforcers in the guidance of goal-directed behavior.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amygdala / cytology
  • Amygdala / physiology*
  • Animals
  • Cognition / physiology
  • Discrimination Learning / physiology*
  • Emotions / physiology
  • Humans
  • Neural Inhibition / physiology
  • Neural Pathways / cytology
  • Neural Pathways / physiology*
  • Prefrontal Cortex / cytology
  • Prefrontal Cortex / physiology*
  • Reward*