Vitamin D analogs as therapeutic agents: a clinical study update

Curr Opin Investig Drugs. 2004 Mar;5(3):320-6.

Abstract

Vitamin D3 is modified by vitamin D3-25-hydroxylase in the liver and 25-hydroxyvitamin D3-1 alpha-hydroxylase in the kidney to form the active metabolite 1 alpha,25-dihydroxyvitamin D3. The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription. 1 alpha,25-dihydroxyvitamin D3 regulates the homeostasis of calcium and phosphorus, and also controls the expression of parathyroid hormone. Chronic renal disease is characterized by reduced synthesis of 1 alpha,25-dihydroxyvitamin D3, inadequate renal phosphate clearance and calcium imbalance, over-stimulation of the parathyroid gland, and increased parathyroid hormone synthesis. This secondary hyperparathyroidism (HPT) can cause renal osteodystrophy unless treated. Several vitamin D analogs are currently available or under investigation for the treatment of secondary HPT, psoriasis and osteoporosis. Additional clinical studies are being conducted for a variety of indications, including bone diseases, cell proliferation disorders and autoimmune diseases. Different vitamin D analogs seem to exhibit differential effects as exemplified by the survival benefit provided by paricalcitol over 1 alpha,25-dihydroxyvitamin D3 for end-stage renal disease patients on hemodialysis. Elucidation of the mechanism of action for the different vitamin D analogs will enhance our understanding of the vitamin D pathway and improve therapeutic uses of these analogs. This review discusses recent progress on the use of vitamin D and its analogs in the management of HPT secondary to chronic renal disease.

Publication types

  • Review

MeSH terms

  • Calcitriol / analogs & derivatives*
  • Calcitriol / therapeutic use
  • Clinical Trials as Topic
  • Ergocalciferols / therapeutic use
  • Humans
  • Hyperparathyroidism, Secondary / drug therapy
  • Hyperparathyroidism, Secondary / etiology
  • Immunosuppressive Agents / therapeutic use
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / physiopathology
  • Vitamin D / analogs & derivatives*
  • Vitamin D / chemistry*
  • Vitamin D / therapeutic use

Substances

  • Ergocalciferols
  • Immunosuppressive Agents
  • Vitamin D
  • paricalcitol
  • Calcitriol
  • seocalcitol