Automatic generation of noise-free time-activity curve with gated blood-pool emission tomography using deformation of a reference curve

IEEE Trans Med Imaging. 2004 Apr;23(4):485-91. doi: 10.1109/TMI.2004.825638.


This paper describes a new method for assessing clinical parameters from a noisy regional time-activity curve (TAC) in tomographic gated blood-pool ventriculography. This method is based on a priori knowledge on the shape of a TAC, and shape approximation. The rejection method was used to generate different random Poisson deviates, covering standard count levels, of six representative TACs in order to test and compare the proposed method with harmonic and multiharmonic reconstruction methods. These methods were compared by evaluating four clinical parameters: time of end systole, amplitude, peak ejection and filling rates. Overall, the accuracy of assessment of these parameters was found to be better with the method described in this paper than with standard multiharmonic fits.

MeSH terms

  • Algorithms*
  • Computer Simulation
  • Expert Systems
  • Gated Blood-Pool Imaging / methods*
  • Heart Ventricles / diagnostic imaging*
  • Heart Ventricles / metabolism
  • Humans
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Metabolic Clearance Rate
  • Models, Biological*
  • Radioisotope Dilution Technique
  • Radiopharmaceuticals / pharmacokinetics
  • Reference Values
  • Stochastic Processes
  • Subtraction Technique*


  • Radiopharmaceuticals