Possible absorption of antidiuretic hormone in isolated rat intestine

Bull Exp Biol Med. 2004 Jan;137(1):1-3. doi: 10.1023/b:bebm.0000024370.53746.ac.

Abstract

Arginine-vasopressin or arginine-vasotocin hormones introduced into the small intestine are absorbed and exert a hydrosmotic effect. The amount of absorbed antidiuretic hormone increased when it is introduced with intestinal peptidase inhibitor aprotinin. These data attest to the possibility of absorption of pituitary hormones (vasotocin and vasopressin) in rat small intestine without losing their physiological activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aprotinin / pharmacology
  • Arginine Vasopressin / pharmacokinetics*
  • Arginine Vasopressin / pharmacology
  • Arginine Vasopressin / physiology
  • In Vitro Techniques
  • Intestinal Absorption*
  • Intestine, Small / metabolism*
  • Osmosis / drug effects
  • Permeability / drug effects
  • Rana temporaria
  • Rats
  • Rats, Wistar
  • Urinary Bladder / drug effects
  • Vasotocin / pharmacokinetics*
  • Vasotocin / pharmacology
  • Vasotocin / physiology

Substances

  • Arginine Vasopressin
  • Aprotinin
  • Vasotocin