Insulin-like growth factors and pancreas beta cells

Eur J Clin Invest. 2004 Apr;34(4):249-55. doi: 10.1111/j.1365-2362.2004.01337.x.


Abstract Insulin-like growth factors (IGFs) have been implicated in normal growth, and especially foetal pancreas beta-cell development. As low birth weight has been implicated in the development of obesity and type 2 diabetes, much research has evolved into the importance of IGF and their signalling pathways for pancreas beta-cell development, and for type 2 diabetes. Insulin-like growth factor-I signalling has a lot in common with insulin signalling, and is involved in diverse cellular effects such as antiapoptosis, protein synthesis, cell growth and mitogenesis. Insulin-like growth factor-II can be bound by the insulin receptor A subtype and the IGF-1 receptor, which may explain its antiapoptotic effect. Various knock-out model studies indicate that absence of IGF-I or the IGF-1 receptor is critical for foetal and postnatal growth. Similarly, knock-out models of post-receptor molecules (such as IRS-2) point to the physiological role of IGFs for pancreas beta-cell development. A beta-cell-specific IGF-1 receptor knock out model indicates the importance of IGF-I for beta-cell function. The Goto-Kakizaki (GK) rat, a model for diabetes, has insufficient beta-cell development, which may be related to its defective IGF-II synthesis. As normal pancreas beta cells adapt to the prevailing insulin resistance with increasing beta-cell function, it is possible that insulin resistance interacts with IGF signalling in pancreas beta cells.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / physiopathology
  • Humans
  • Insulin / metabolism
  • Insulin Resistance / physiology
  • Insulin-Like Growth Factor I / physiology
  • Insulin-Like Growth Factor II / physiology
  • Islets of Langerhans / growth & development*
  • Islets of Langerhans / physiopathology
  • Rats
  • Signal Transduction / physiology
  • Somatomedins / physiology*


  • Insulin
  • Somatomedins
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II