Sympathetic hyperactivity in chronic kidney disease: pathogenesis, clinical relevance, and treatment

Kidney Int. 2004 May;65(5):1568-76. doi: 10.1111/j.1523-1755.2004.00552.x.


Cardiovascular morbidity and mortality importantly influence live expectancy of patients with chronic renal disease (CKD). Traditional risk factors are usually present, but several other factors have recently been identified. There is now evidence that CKD is often characterized by an activated sympathetic nervous system. This may contribute to the pathogenesis of renal hypertension, but it may also adversely affect prognosis independently of its effect on blood pressure. The purpose of this review is to summarize available knowledge on the role of the sympathetic nervous system in the pathogenesis of renal hypertension, its clinical relevance, and the consequences of this knowledge for the choice of treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chronic Disease
  • Humans
  • Hypertension, Renal / etiology
  • Hypertension, Renal / physiopathology
  • Hypertension, Renal / therapy
  • Kidney / injuries
  • Kidney Diseases / physiopathology*
  • Kidney Diseases / therapy
  • Nitric Oxide / antagonists & inhibitors
  • Renal Dialysis
  • Renin-Angiotensin System / physiology
  • Sympathetic Nervous System / physiopathology*


  • Nitric Oxide