Molecular polymorphism in Drosophila melanogaster and D. simulans: what have we learned from recent studies?

Genetica. 2004 Mar;120(1-3):79-86. doi: 10.1023/b:gene.0000017632.08718.df.

Abstract

We present a review of recent studies of molecular polymorphism in Drosophila melanogaster and D. simulans. The availability of African and non-African samples for these species makes it possible to compare microsatellite and DNA sequence polymorphism between these species, both inside and outside their native regions. There are four main results: (i) variability is larger in African populations; (ii) variation is usually higher on the autosomes, except for African D. melanogaster; (iii) DNA sequence variation is higher on D. simulans than on D. melanogaster autosomes; (iv) the ratio of replacement to silent polymorphisms is higher for D. melanogaster autosomal loci. We summarize the main hypotheses put forward to explain these results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa
  • Animals
  • DNA / genetics
  • Drosophila / genetics*
  • Drosophila melanogaster / genetics*
  • Genetic Linkage
  • Genetic Variation
  • Microsatellite Repeats
  • Models, Genetic
  • Polymorphism, Genetic*
  • Species Specificity
  • X Chromosome

Substances

  • DNA