Effect of Bacopa monniera and Azadirachta indica on gastric ulceration and healing in experimental NIDDM rats

Indian J Exp Biol. 2004 Apr;42(4):389-97.


Gastric ulcers were induced in normal/NIDDM rats by various physical (2 hr cold restraint stress and 4 hr pylorus ligation) and chemical agents (ethanol, 1 ml/200 g, oral, 1 hr before; aspirin, 200 mg/kg, oral, 4 hr) and duodenal ulcers were induced by cysteamine (40 mg/200 g). Ulcer healing activity was studied in gastric ulcers induced by acetic acid (50%) and HCI (0.6 M). The result indicated that in both, normal and NIDDM rats, B. monniera extract (BME, 20-100 mg/kg) did not show any significant effect on blood glucose level, while A. indica (AIE, 250-1000 mg/kg) significantly decreased it. However, both BME (50 mg/kg) and AIE (500 mg/kg) showed significant anti-ulcer and ulcer-healing activities in normal and NIDDM rats. Further, the present results also indicated that the ulcer protective effects of BME was more pronounced in non-diabetic, while that of AIE was more in NIDDM rats. The anti-ulcer and ulcer-healing activities of BME and AIE may be due to their effects on various mucosal offensive and defensive factors, and correction of blood sugar level by AIE may help to have more ulcer protective effect in NIDDM rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid / toxicity
  • Animals
  • Anti-Ulcer Agents / therapeutic use
  • Aspirin / toxicity
  • Azadirachta / chemistry*
  • Bacopa / chemistry*
  • Cold Temperature
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Type 2 / chemically induced
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Dose-Response Relationship, Drug
  • Duodenal Ulcer / chemically induced
  • Duodenal Ulcer / drug therapy*
  • Ethanol / toxicity
  • Female
  • Male
  • Phytotherapy*
  • Plant Extracts / therapeutic use
  • Rats
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / drug therapy*
  • Wound Healing / drug effects


  • Anti-Ulcer Agents
  • Plant Extracts
  • Ethanol
  • Acetic Acid
  • Aspirin