Hidden neuronal correlations in cultured networks

Phys Rev Lett. 2004 Mar 19;92(11):118102. doi: 10.1103/PhysRevLett.92.118102. Epub 2004 Mar 19.


Utilization of a clustering algorithm on neuronal spatiotemporal correlation matrices recorded during a spontaneous activity of in vitro networks revealed the existence of hidden correlations: the sequence of synchronized bursting events (SBEs) is composed of statistically distinguishable subgroups each with its own distinct pattern of interneuron spatiotemporal correlations. These findings hint that each of the SBE subgroups can serve as a template for coding, storage, and retrieval of a specific information.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Animals
  • Brain / cytology
  • Brain / metabolism
  • Brain / physiology
  • Calcium / metabolism
  • Models, Neurological*
  • Nerve Net / physiology*
  • Neurons / metabolism
  • Neurons / physiology*
  • Rats


  • Calcium