Therapeutic relevance of pharmacokinetics and pharmacodynamics

Semin Oncol. 1992 Aug;19(4 Suppl 11):8-13.


Most antineoplastic drugs have a narrow therapeutic index. The medical world's incomplete understanding of the variability of pharmacokinetics and pharmacodynamics has led to dosing problems with these agents. Basic understanding of linear and nonlinear pharmacokinetic models as well as interpatient and intrapatient variability is necessary to optimize dosing. Pharmacodynamic information relates pharmacokinetic information to clinical outcome.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacokinetics*
  • Antineoplastic Agents / pharmacology
  • Humans
  • Models, Biological
  • Neoplasms / drug therapy


  • Antineoplastic Agents