Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway

Cancer Cell. 2004 Apr;5(4):329-39. doi: 10.1016/s1535-6108(04)00081-9.

Abstract

Molecular mechanisms associated with tumor metastasis remain poorly understood. Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors. Periostin is overexpressed in more than 80% of human colon cancers examined with highest expression in metastatic tumors. Periostin expression dramatically enhanced metastatic growth of colon cancer by both preventing stress-induced apoptosis in the cancer cells and augmenting endothelial cell survival to promote angiogenesis. At the molecular level, periostin activated the Akt/PKB signaling pathway through the alpha(v)beta(3) integrins to increase cellular survival. These data demonstrated that the survival-promoting function is crucial for periostin to promote tumor metastasis of colon cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apoptosis
  • Cell Adhesion Molecules / metabolism*
  • Cell Hypoxia
  • Cell Survival
  • Colon / metabolism
  • Colon / pathology
  • Colonic Neoplasms / metabolism
  • Colonic Neoplasms / pathology*
  • Endothelial Cells / metabolism
  • Endothelial Cells / pathology
  • Female
  • Humans
  • Integrin alphaVbeta3 / metabolism
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / secondary*
  • Mice
  • Mice, Nude
  • Protein-Serine-Threonine Kinases*
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-akt
  • Signal Transduction
  • Tumor Cells, Cultured

Substances

  • Cell Adhesion Molecules
  • Integrin alphaVbeta3
  • POSTN protein, human
  • Postn protein, mouse
  • Proto-Oncogene Proteins
  • AKT1 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt