A structural view of the COPII vesicle coat

Curr Opin Struct Biol. 2004 Apr;14(2):147-53. doi: 10.1016/j.sbi.2004.02.002.


The COPII vesicle coat coordinates the budding of transport vesicles from the endoplasmic reticulum in the initial step of the secretory pathway. The coat orchestrates a sequence of events including self-assembly on the membrane, cargo and SNARE molecule selection, and deformation of the membrane into a bud to drive vesicle fission. Recent molecular-level studies have helped to explain how the three components of yeast COPII - Sar1 GTPase, the Sec23/24 subcomplex and the Sec13/31 subcomplex - combine to organize this complex process.

Publication types

  • Review

MeSH terms

  • COP-Coated Vesicles / metabolism*
  • Carrier Proteins / metabolism
  • GTPase-Activating Proteins
  • Golgi Apparatus / metabolism
  • Guanosine Triphosphate / metabolism
  • Membrane Proteins / metabolism*
  • Models, Molecular*
  • Monomeric GTP-Binding Proteins / metabolism
  • Nuclear Pore Complex Proteins
  • Phosphoproteins / metabolism
  • Protein Transport / physiology
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Vesicular Transport Proteins


  • Carrier Proteins
  • GTPase-Activating Proteins
  • Membrane Proteins
  • Nuclear Pore Complex Proteins
  • Phosphoproteins
  • SEC13 protein, S cerevisiae
  • SEC23 protein, S cerevisiae
  • SEC24 protein, S cerevisiae
  • SEC31 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Vesicular Transport Proteins
  • Guanosine Triphosphate
  • Monomeric GTP-Binding Proteins
  • SAR1 protein, S cerevisiae