Tumor necrosis factor family ligand-receptor binding

Curr Opin Struct Biol. 2004 Apr;14(2):154-60. doi: 10.1016/j.sbi.2004.03.003.


Ligands and receptors of the tumor necrosis factor (TNF) superfamily have pivotal roles in the development and function of the immune system. The growing pool of data on TNF from structural and biochemical studies suggests that the higher order clustering of TNF family ligands could play an essential role in signal transduction initiation for this superfamily. The identification of new structural modules of TNF family receptors, as well as interaction modes between ligands and receptors, greatly expands our knowledge of how TNF family ligands and receptors determine specificity among diverse family members and between two closely related family members.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Ligands
  • Molecular Structure
  • Receptors, Tumor Necrosis Factor / chemistry
  • Receptors, Tumor Necrosis Factor / metabolism*
  • Signal Transduction / physiology*
  • Tumor Necrosis Factor-alpha / chemistry
  • Tumor Necrosis Factor-alpha / metabolism*


  • Ligands
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha