Isolation of Salmonella Enterica Serotype Choleraesuis Resistant to Ceftriaxone and Ciprofloxacin

Lancet. 2004 Apr 17;363(9417):1285-6. doi: 10.1016/S0140-6736(04)16003-0.


Salmonella enterica serotype choleraesuis (S choleraesuis) usually causes systemic infections in man that need antimicrobial treatment. We isolated a strain of S choleraesuis that was resistant to ceftriaxone and ciprofloxacin from a patient with sepsis. Ciprofloxacin resistance was associated with mutations in gyrA and parC, whereas the ampC gene (bla(CMY-2)), responsible for ceftriaxone resistance, was carried by a transposon-like mobile element. This element was found inserted into finQ of a potentially transmissible 140 kb plasmid, with an 8 bp direct repeat flanking the junction regions. The appearance of this resistant S choleraesuis is a serious threat to public health, and thus constant surveillance is warranted.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ceftriaxone / pharmacology*
  • Ciprofloxacin / pharmacology*
  • Drug Resistance, Bacterial
  • Genes, Bacterial / genetics
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Plasmids
  • Salmonella Infections / drug therapy
  • Salmonella Infections / microbiology
  • Salmonella enterica / drug effects*
  • Salmonella enterica / genetics
  • Salmonella enterica / isolation & purification
  • Sepsis / microbiology
  • Serotyping


  • Ciprofloxacin
  • Ceftriaxone