Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Mar 22;15(4):691-4.
doi: 10.1097/00001756-200403220-00023.

The Pineal Gland and Anxiogenic-Like Action of Fluoxetine in Mice

Affiliations

The Pineal Gland and Anxiogenic-Like Action of Fluoxetine in Mice

Tolga Uz et al. Neuroreport. .

Abstract

Fluoxetine produces initial paradoxical anxiogenic effect in some patients. In an elevated plus-maze (EPM), fluoxetine triggers an anxiogenic-like effect in rodents. Behavioral responses to psychoactive drugs can be modified by the pineal gland. We assessed the actions of fluoxetine in the EPM in melatonin-proficient C3H mice, melatonin-deficient C57BL6 mice, and in sham-operated and pinealectomized mice. Mice were assayed 30 min after the first injection and on day 14. Protracted fluoxetine treatment reduced the time on the anxiogenic open arms and increased the entries into the safe closed arms in sham-operated C3H mice. Fluoxetine was ineffective in pinealectomized C3H or C57BL6 mice. It is possible that the pineal system contributes to the previously observed anxiogenic action of fluoxetine in humans.

Similar articles

See all similar articles

Cited by 4 articles

Publication types

MeSH terms

Feedback