An essential role for protein synthesis in oncogenic cellular transformation

Oncogene. 2004 Apr 19;23(18):3145-50. doi: 10.1038/sj.onc.1207550.


The induction and maintenance of oncogenic transformation requires interference with the controls that regulate translation and transcription. The PI 3-kinase pathway, which shows gain of function in numerous and diverse human cancers, generates signals that have a positive effect on the initiation of protein synthesis. Here we review the components of the PI 3-kinase signaling pathway and the mRNA-binding protein YB-1, exploring their roles in protein synthesis and oncogenic cell transformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / metabolism*
  • Humans
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases / physiology
  • Phosphoric Monoester Hydrolases / physiology
  • Protein Biosynthesis*
  • Protein-Serine-Threonine Kinases*
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-akt
  • Ribosomal Protein S6 Kinases / metabolism
  • Tumor Suppressor Proteins / physiology


  • Proto-Oncogene Proteins
  • Tumor Suppressor Proteins
  • Phosphatidylinositol 3-Kinases
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Ribosomal Protein S6 Kinases
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human