Fate of a single dose of the 14C-labelled mycotoxin, fumonisin B1, in rats

Toxicon. 1992 Jul;30(7):768-70. doi: 10.1016/0041-0101(92)90011-s.

Abstract

The fate of the mycotoxin, fumonisin B1, (FB1) dosed to rats by i.p. injection and by gavage was traced using 14C-labelled FB1. Twenty-four hours after i.p. injection, 66% of the radioactivity was recovered in faeces, 32% in urine, 1% in liver and trace amounts (less than 1%) in kidney and red blood cells. When dosed by gavage, all (101%) radioactivity was recovered in faeces and trace amounts were found in urine, liver, kidney and red blood cells. The bulk of the radioactivity recovered was unmetabolized FB1.

MeSH terms

  • Animals
  • Carbon Radioisotopes
  • Carcinogens, Environmental / pharmacokinetics*
  • Fumonisins*
  • Male
  • Mycotoxins / pharmacokinetics*
  • Rats
  • Tissue Distribution

Substances

  • Carbon Radioisotopes
  • Carcinogens, Environmental
  • Fumonisins
  • Mycotoxins
  • fumonisin B1