All in the family: aldose reductase and closely related aldo-keto reductases

Cell Mol Life Sci. 2004 Apr;61(7-8):737-49. doi: 10.1007/s00018-003-3402-3.

Abstract

Aldose reductase catalyzes the first step in the polyol pathway and is thought to be involved in the pathogenesis of diabetic complications. In addition to polyol synthesis, aldose reductase may have multiple other activities that intersect with signal processing and oxidative defense mechanisms. Multiple aldose reductase-like proteins have been discovered to have structures and catalytic properties that broadly overlap those of aldose reductase. This chapter will summarize new insights into properties and functions of aldose reductase and closely related members of the aldo-keto reductase enzyme superfamily.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alcohol Oxidoreductases / genetics
  • Alcohol Oxidoreductases / metabolism*
  • Aldehyde Reductase / antagonists & inhibitors
  • Aldehyde Reductase / chemistry
  • Aldehyde Reductase / genetics
  • Aldehyde Reductase / metabolism*
  • Aldo-Keto Reductases
  • Amino Acid Sequence
  • Animals
  • Diabetes Mellitus / metabolism
  • Glucose / metabolism
  • Humans
  • Molecular Sequence Data
  • Osmosis
  • Polymers / metabolism
  • Protein Kinase C / metabolism
  • Proteins / metabolism
  • Sequence Alignment
  • Signal Transduction / physiology

Substances

  • Polymers
  • Proteins
  • polyol
  • Alcohol Oxidoreductases
  • Aldo-Keto Reductases
  • Akr1b7 protein, mouse
  • Aldehyde Reductase
  • AKR7A5 protein, mouse
  • Protein Kinase C
  • Glucose