Cell polarity and cell diversification during early mouse embryogenesis

Trends Genet. 1992 Aug;8(8):274-9. doi: 10.1016/0168-9525(92)90253-z.


At the eight-cell stage of mouse development, the organization of blastomeres changes from radially symmetrical to polarized. This acquisition of cell polarity, followed by asymmetric divisions, leads to the formation of two phenotypically different cell types, which give rise to the first two cell lineages of the mouse blastocyst embryo, trophectoderm and the inner cell mass. Cell fate, controlled by positional information, is not irreversibly fixed during differentiation, providing the embryo with considerable developmental flexibility.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cell Polarity*
  • Embryonic and Fetal Development*
  • Mice