The TATA-binding protein: a central role in transcription by RNA polymerases I, II and III

Trends Genet. 1992 Aug;8(8):284-8. doi: 10.1016/0168-9525(92)90255-3.

Abstract

The TATA-box-binding protein, first noted for its association with the general transcription factor TFIID, has recently been shown to be required for transcription by all three classes of nuclear RNA polymerase found in eukaryotes. As such, it plays a unique and pivotal role in gene expression in higher organisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism*
  • Humans
  • RNA Polymerase I / metabolism*
  • RNA Polymerase II / metabolism*
  • RNA Polymerase III / metabolism*
  • TATA Box*
  • TATA-Box Binding Protein
  • Transcription Factors / metabolism*
  • Transcription, Genetic

Substances

  • DNA-Binding Proteins
  • TATA-Box Binding Protein
  • Transcription Factors
  • RNA Polymerase II
  • RNA Polymerase I
  • RNA Polymerase III