Do metastases metastasize?

J Pathol. 2004 May;203(1):515-8. doi: 10.1002/path.1544.


Metastatic disease is a major cause of morbidity and mortality. However, it is not clear if all metastases originate from the primary tumour or whether metastases themselves have the capacity to metastasize. In this review, the evidence for the latter phenomenon, and its biological and clinical implications, is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Disease Progression
  • Humans
  • Lymphatic Metastasis / diagnosis
  • Lymphatic Metastasis / pathology
  • Lymphatic Metastasis / physiopathology
  • Neoplasm Metastasis / diagnosis
  • Neoplasm Metastasis / pathology
  • Neoplasm Metastasis / physiopathology*
  • Time Factors