Serum interleukin-6, procalcitonin and C-reactive protein levels in subjects with active Behçet's disease

J Eur Acad Dermatol Venereol. 2004 May;18(3):318-20. doi: 10.1111/j.1468-3083.2004.00907.x.


Background: Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and cytokines, including serum interleukin (IL)-6, IL-8 and IL-10, and tumour necrosis factor-alpha (TNF-alpha) have been proposed as disease activity markers in Behçet's disease (BD), although studies have shown conflicting results for IL-6. Serum procalcitonin (PCT) levels in active BD have not yet been investigated.

Objective: The aim of the present study was to determine the reliability of serum IL-6 and PCT levels as well as CRP as biological markers for activity of BD.

Methods: Serum PCT, IL-6 and CRP protein levels were measured in patients with active BD (n = 15) and in healthy control subjects (n = 15). IL-6 and PCT levels were measured in serum by chemiluminescent assay. In addition, a nephelometric method was used to analyse CRP concentrations in serum.

Results: Serum CRP and IL-6 values were significantly higher in the subjects with active disease than in the healthy controls (P < 0.05), but there was no significant difference in the levels of PCT in the two groups.

Conclusion: The results of our study suggest that serum CRP and IL-6 levels are elevated in patients with active BD, but that serum PCT values are not elevated in these patients.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Behcet Syndrome / blood
  • Behcet Syndrome / diagnosis*
  • Biomarkers / blood
  • C-Reactive Protein / metabolism*
  • Calcitonin / analysis
  • Calcitonin / blood*
  • Calcitonin Gene-Related Peptide
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Humans
  • Interleukin-6 / blood*
  • Male
  • Middle Aged
  • Prognosis
  • Protein Precursors / analysis
  • Protein Precursors / blood*
  • Risk Assessment
  • Sensitivity and Specificity
  • Severity of Illness Index


  • Biomarkers
  • CALCA protein, human
  • Interleukin-6
  • Protein Precursors
  • Calcitonin
  • C-Reactive Protein
  • Calcitonin Gene-Related Peptide