Mumps-induced corneal endotheliitis

Cornea. 2004 May;23(4):400-2. doi: 10.1097/00003226-200405000-00017.


Objective: To report two cases of corneal endotheliitis following mumps parotitis.

Methods: Observational case reports of two patients presenting with sudden unilateral diminution of vision while they were in the resolution phase of mumps parotitis.

Results: Central corneal edema with no associated epithelial involvement or iridocyclitis was confirmed on slit-lamp biomicroscopy. Specular microscopy confirmed an increased corneal thickness with corneal endothelial abnormalities. The diagnosis of mumps virus infection was established through detection of IgM antibody in serum samples of the patients using enzyme-linked immunosorbent assay (ELISA). The routine investigations for other systemic diseases were negative.

Conclusions: Corneal endotheliitis as a sequela to mumps is a new reported association. Timely treatment with topical steroids led to resolution of the disease with full visual recovery without any residual symptoms or signs.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Viral / blood
  • Corneal Edema / etiology*
  • Endothelium, Corneal / pathology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin M / analysis
  • Keratitis / etiology*
  • Male
  • Mumps / complications*
  • Mumps / diagnosis


  • Antibodies, Viral
  • Immunoglobulin M