Towing of sensory axons by their migrating target cells in vivo

Nat Neurosci. 2004 May;7(5):491-2. doi: 10.1038/nn1235. Epub 2004 Apr 18.

Abstract

Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Axons / physiology*
  • Cell Communication / genetics*
  • Cell Movement / physiology*
  • Chemokine CXCL12
  • Chemokines, CXC / metabolism
  • Diagnostic Imaging / methods
  • Embryo, Nonmammalian
  • Green Fluorescent Proteins
  • Growth Cones
  • In Situ Hybridization / methods
  • Luminescent Proteins
  • Neurons, Afferent / cytology
  • Neurons, Afferent / physiology*
  • Neurons, Afferent / transplantation
  • Receptors, CXCR4 / genetics
  • Signal Transduction
  • Time Factors
  • Transplantation / methods
  • Zebrafish
  • Zebrafish Proteins / genetics

Substances

  • CXCR4b protein, zebrafish
  • Chemokine CXCL12
  • Chemokines, CXC
  • Luminescent Proteins
  • Receptors, CXCR4
  • Zebrafish Proteins
  • Green Fluorescent Proteins